Key Articles:

  • Phase I/II parallel double-blind randomized controlled clinical trial of perispinal etanercept for chronic stroke: improved mobility and pain alleviation. S. J. Ralph, Opin Investig Drugs, 2020: p. 1-16.
  • Immediate Resolution of Hemispatial Neglect and Central Post-Stroke Pain After Perispinal Etanercept: Case Report. Edward Tobinick MD, Clinical Drug Investigation, 2019 Oct 22, epub, (Free Download).
  • Perispinal etanercept advances as a neurotherapeutic. Edward Tobinick MD, Expert Review Neurotherapeutics, 2018:1-3. (Free Download).
  • Perispinal Etanercept for Traumatic Brain Injury. Edward Tobinick MD, Kinssies R, Kim N, Chapter 7, pp. 109-29, in New Therapeutics for Traumatic Brain Injury, KA Heidenreich, editor. Cambridge, Mass.: Academic Press. 2017. (Link to Book Chapter).
  • On Overcoming Barriers to Application of Neuroinflammation Research. Edward Tobinick MD, Ignatowski, T., Spengler, R. In: Abreu GEA, ed. Mechanisms of Neuroinflammation: InTechOpen; 2017. (Free Download).
  • Perispinal Delivery of CNS Drugs.  Edward Tobinick MD. CNS Drugs, 2016;30(6):469-80. (Free Download).
  • Authors’ Reply … Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence. Ignatowski TA, Spengler RN, Tobinick E. CNS Drugs, December 2014, 28(12):1207-13. (Free Download).
  • Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence. Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF, Tobinick E. CNS Drugs, August 2014, 28(8):679-697, published online 27 May 2014. (Free Download).
  • Immediate Neurological Recovery Following Perispinal Etanercept Years After Brain Injury. Edward Tobinick MD, Rodriguez-Romanacce H, Levine A, Ignatowski TA, Spengler RN. Clin Drug Investig. 2014 May;34(5):361-6. (Link to Journal Article).
  • Studies of Selective TNF Inhibitors in the Treatment of Brain Injury From Stroke and Trauma: A Review of Evidence to Date. Tuttolomondo, A., R. Pecoraro, and A. Pinto, Drug Design, Development and Therapy, 2014(November). 8: p. 2221-2239. (Free Download).
  • New Hope for Survivors of Stroke and Traumatic Brain Injury. Clark, I., CNS Drugs, 2012. 26(12): p. 1071-2; (Free Download).
  • Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury – An Observational Study Involving 629 Consecutive Patients Treated with Perispinal Etanercept. Edward Tobinick MD, Kim NM, Reyzin G, et. al. CNS Drugs. 2012 Dec;26(12):1051-70. (Link to Journal Article).
  • Rapid Improvement of Chronic Stroke Deficits After Perispinal Etanercept: Three Consecutive Cases. Edward Tobinick MD. CNS Drugs. 2011 Feb 1; 25(2):145-155. (Link to Journal Article).
  • Perispinal Etanercept: A New Therapeutic Paradigm in Neurology. Edward Tobinick MD. Expert Review of Neurotherapeutics. 2010 Jun;10(6):985-1002. (Free Download).
  • Perispinal etanercept for neuroinflammatory disorders. Edward Tobinick MD. Drug Discovery Today. 2009 Feb;14(3-4):168-77. (Full Text Link).
  • Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging. Edward Tobinick MD, K Chen PhD, X Chen PhD. BMC Res Notes. 2009 Feb 27;2:28. (Free Download).
  • Paths to acceptance. The advancement of scientific knowledge is an uphill struggle against ‘accepted wisdom’. Wolinsky H. EMBO Rep. 2008 May;9(5):416-8. (Free Full Text).